Diagnosis of Lupus Cerebritis with Balint Syndrome: A Unique Case Report
Juliana Cazzaniga1*, Cesar E Jara Silva2, Solomon Nittala2 and David Filippi2
1 Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
2 Neurology Department, Larkin Community Hospital Palm Springs Campus, Miami, FL, USA.
*Corresponding Author: Juliana Cazzaniga, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
DOI: https://doi.org/10.58624/SVOANE.2023.04.097
Received: June 19, 2023 Published: July 04, 2023
Abstract
Introduction: Among the wide variety of clinical manifestations in Systemic Lupus Erythematosus (SLE), cognitive dysfunction (CD) is a subtle finding, where the reported prevalence ranges from 3-88% due to CD assessment inconsistencies and challenges with SLE correlations. Cognitive dysfunction may also be a cornerstone element for a diagnosis of Neuropsychiatric Systemic Lupus Erythematosus (NP-SLE). We present a case of Lupus Cerebritis displaying seizures and oculomotor dysfunctions referred to as Balint Syndrome. To our knowledge, no publications to date have shown a correlation between Lupus Cerebritis and Balint Syndrome.
Case Report: A 35-year-old female with a history of lupus, seizures, and migraines presented complaining of a severe headache associated with vomiting. The patient stated the onset of her symptoms was three days prior and had been worsening. While in the emergency room, the patient had a generalized tonic-clonic seizure lasting around 2 minutes at which point neurology was consulted for seizure management. The patient had been seen about a year prior for similar complaints and was started on Keppra to control her epilepsy. The patient was seizure free for about 6 months so Keppra was discontinued.
Discussion: A wide array of symptoms are associated with Lupus Cerebritis, which is a rare manifestation following a diagnosis of SLE. Our patient was having seizures and complaints of migraine with severe Balint Syndrome consisting of oculomotor apraxia, optic ataxia, and simultagnosia. Due to some patients’ rapid decline following a diagnosis of SLE and the complex diversity of symptoms, it is crucial to prevent organ failure by treating them immediately, and furthermore, to equip and educate clinicians in identifying atypical presentations.
Conclusion: Due to the complexity of autoimmune diseases, patients may present with a plethora of symptomatology, ranging from mild to severe, making a thorough medical history and physical examination imperative elements of a complete workup. Since NP-SLE is a nuanced diagnosis requiring specific management, it is essential to have close follow -ups with neurology.
Keywords: Systemic Lupus Erythematosus, Lupus Cerebritis, autoimmune disease, seizures.
Citation: Cazzaniga J, Silva CEJ, Nittala S, Filippi D. Diagnosis of Lupus Cerebritis with Balint Syndrome: A Unique Case Report. SVOA Neurology 2023, 4:4, 89-93.
