Hypothermia as a Treatment Option for Intra and Post Ischemic Stroke
Manik Mathur1* and Rupjyoti Das2
1MBBS, PostGrad Diploma (UK), Ph.D. Clinical Neurosciences, Member of American Academy of Neurology Consultant Neurologist, Division of Clinical Neurosciences, GNRC Hospitals, Assam, India
2MBBS, MD, DNB, HOD and Senior Consultant, Department of Clinical Neurology, GNRC Hospitals, Assam, India
*Corresponding Author: Dr. Manik Mathur, MBBS, PostGrad Diploma (UK), Ph.D. Clinical Neurosciences, Member of American Academy of Neurology Consultant Neurologist, Division of Clinical Neurosciences, GNRC Hospitals, Assam, India
Received: January 27, 2022 Published: February 24, 2022
Abstract
Neuroinflammation is a key component in the ischemic cascade following cerebral ischemic insult that results into tissue damage, leakage in the blood-brain barrier and death in the sub-acute phase. Failure of anti-inflammatory drugs to improve outcome in clinical settings have suggested its response following an ischemic attack is detrimental. Hypothermia is a robust neuroprotectant and has consistently shown benefit against a variety of brain injuries at the experimental level. It has recently been shown to improve neurological outcome in comatose survivors of cardiac arrest and neonatal hypoxic ischemia. Although until now, therapeutic hypothermia doesn’t categorise under any therapeutic standards of parameters, but it is well accepted that cooling should be started as soon as possible following an ischemic attack. This review discusses the protective influence of hypothermia on the neuroinflammatory response.
Keywords: Hypothermia, Ischemic, stroke, cerebral ischemia
Citation: Mathur M, Das R. “Hypothermia as a Treatment Option for Intra and Post Ischemic Stroke”. SVOA Neurology 3:2 (2022) Pages 36-40.
