Antibacterial Activity of Some Medicinal Plants Against Extended Spectrum Beta Lactamase (ESBL) Producing Escherichia coli and Klebsiella pneumonia in Khartoum State – Sudan
Nashwa Azhari1, Mohamed H. Arbab2*, Ahmed Khidir3, Mohamed M. Babeker3 and Sahar Mohammed Sedahmed3
1 Sudan International University - Faculty of Medical Laboratory Sciences - Department of Medical Microbiology - Khartoum, Sudan.
2 Associate Professor – Medical Microbiology Faculty of Medical Laboratory Sciences - Omdurman Ahlia University, Khartoum, Sudan.
3 Faculty of Medical Laboratory Sciences - Omdurman Ahlia University, Khartoum, Sudan.
*Corresponding Author: Mohamed H. Arbab, Associate Professor, Medical Microbiology Faculty of Medical Laboratory Sciences, Omdurman Ahlia University, Sudan Khartoum, Sudan.
DOI: https://doi.org/10.58624/SVOAMB.2024.05.051
Received: August 17, 2024 Published: September 10, 2024
Abstract
The rising threat of antimicrobial resistance, particularly among Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria, has spurred interest in alternative sources of antibacterial agents. This study evaluates the antibacterial efficacy of three medicinal plants—Acacia nilotica (Fabaceae), Syzygium aromaticum (Myrtaceae), and Ziziphus spina-christi (Rhamnaceae) against ESBL-producing Escherichia coli and Klebsiella pneumoniae. Clinical isolates of these pathogens were obtained from hospitals in Khartoum, Sudan. The plants’ active compounds were extracted using 80% ethanol, and their antibacterial activity was assessed via the cup-plate agar diffusion method. Additionally, the Minimum Inhibitory Concentration (MIC) of each extract was determined. The results indicated that A. nilotica and S. aromaticum extracts exhibited significant antibacterial activity, while Z. spina-christi demonstrated no effect against the tested strains. These findings underscore the potential of A. nilotica and S. aromaticum as sources for developing novel antibacterial agents targeting ESBL-producing pathogens.
Keywords: Antimicrobial resistance, ESBL, Escherichia coli, Klebsiella pneumoniae, Medicinal plants, Antibacterial activity.
Citation: Azhari N, Arbab MH, KhidiAr, Babeker MM, Sedahmed SM. Antibacterial Activity of Some Medicinal Plants Against Extended Spectrum Beta Lactamase (ESBL) Producing Escherichia coli and Klebsiella pneumonia in Khartoum State – Sudan. SVOA Microbiology 2024, 5:4, 136-142. doi:10.58624 SVOAMB.2024.05.051
