Platelet Rich Fibrin (PRF) Gel as Efficient Vehicle for Local Drug Delivery in Minor Oral Surgical Defects
Aim and Objectives: To evaluate the effect of platelet rich fibrin (PRF) gel as a vehicle for delivery of diclofenac sodium following transalveolar extraction of impacted mandibular third molar.
Methods: A total of 50 patients for disimpaction were randomly allocated in two equal groups; experimental (25patient) and control (25patient). In experimental group, PRF gel with diclofenac sodium was placed in the extraction socket, whereas in control group only PRF gel was placed. The objective of the study was to compare clinical parameters especially the postoperative pain, swelling, interincisal distance, wound dehiscence, dry socket, soft tissue healing, and infection which were assessed on 1st, 3rd and 7th day following surgical disimpaction.
Results:Results showed significant lower pain scores, reduced facial swelling and improved interincisal opening in experimental group postoperatively when compared to control group.
Conclusion: The present study concludes that the use of simple, cost- effective method of autologous PRP gel as vehicle to localised deliver diclofenac sodium may be beneficial to enhance the wound healing process, promotes bone regeneration and reduced pain.
Keywords: Platelet rich fibrin, Mandibular molar socket healing, diclofenac sodium
Citation: Pillai AK, Thomas S, Seth S, Jain N, Chobey A. “Platelet Rich Fibrin (PRF) Gel as Efficient Vehicle for Local Drug Delivery in Minor Oral Surgical Defects”. SVOA Dentistry 2:5 (2021) Pages 185-191.
