Non-Palliative Treatment and Follow-Up of Children with Genetic Forms of Nephrotic Syndrome: A Narrative Mini-Review
Marcelo de Sousa Tavares1,3*, Ana Carolina Resende Caldeira2 and Maria Clara Moreira de Oliveira2
1 Professor, Child and Adolescent Health, Faculdade de Minas Gerais (FAMINAS), Brazil.
2 Undergraduate Student, Faculdade de Minas (FAMINAS), Brazil.
3 Pediatric Nephrology Unit, Santa Casa de Belo Horizonte, Brazil.
*Corresponding Author: Marcelo de Sousa Tavares, Professor, Child and Adolescent Health, Faculdade de Minas Gerais (FAMINAS), Brazil.
DOI: https://doi.org/10.58624/SVOAPD.2023.02.041
Received: July 12, 2023 Published: July 28, 2023
Abstract
Nephrotic syndrome is the major clinic presentation of glomerulopathies in childhood. Steroid-unresponsiveness is the main indication for kidney biopsy and is closely related to genetic causes. However, the identification of more than 60 genes in the last 2 decades led to the need of new approaches to delay progression to chronic kidney disease and the need for kidney replacement therapy. The current review aimed to identify non-palliative therapeutical approaches to genetic forms of nephrotic syndrome in children and their follow-up. Genetic mutations play a significant role in the pathogenesis of nephrotic syndrome, influencing the choice of treatment strategies and individual patient outcomes. Calcineurin-inhibitors, coenzyme Q-10 supplementation and other drugs may reduce proteinuria and decrease the progressive decline of glomerular filtration rate.
Keywords: Steroid, Resistant nephrotic syndrome, Children, Genetic heterogeneity, Treatment
Citation: Tavares MS, Caldeira ACR, Oliveira MCM. Non-Palliative Treatment and Follow-Up of Children with Genetic Forms of Nephrotic Syndrome: A Narrative Mini-Review. SVOA Paediatrics 2023, 2:4, 98-101.