Role of Neurofilament Light Chain as A Biomarker in Neurological Disorders: A Literature Review
Mohamed Elsayed Abd-ElHady1*, Imane Yassine2, Ehab Ahmed Hashish3, Maha Mohamed Anani4 and Mohamed Ibraheem Negm5
1 Assistant lecturer of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
2 Lecturer of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
3 Lecturer of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
4 Prof. of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
5 Prof. of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
*Corresponding Author: Mohamed Elsayed Abd-ElHady, Assistant lecturer of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
DOI: https://doi.org/10.58624/SVOANE.2023.04.099
Received: June 15, 2023 Published: July 10, 2023
Abstract
Neurofilament light chain (NfL) is a main element of neurons’ structure which is exclusively confined to the neuroaxonal compartment, NfL therefore provides an advantage over other potential biomarkers since it’s highly selective for neuronal cell injury and eventual neuronal cell death. Independent of etiology, NfL levels in CSF and blood increase above normal in response to neuronal damage and neurodegeneration, making it a suitable candidate as a biomarker in these circumstances. Biomarkers of neuronal injury and neurodegeneration have the potential to enhance diagnostic accuracy, disease monitoring, and prognosis.
Keywords: Neurofilament, NFL, biomarker, CSF, blood, Neurodegeneration, Neuronal injury.
Citation: Abd-ElHady ME, Yassine I, Hashish EA, Anani MM, Negm MI. Role of Neurofilament Light Chain as A Biomarker in Neurological Disorders: A Literature Review. SVOA Neurology 2023, 4:4, 98-102.
