Effect of Metformin on Adipose Tissue Degeneration During Obesity
Cesar Elpidio Rodríguez Cervantes1* and Clara Alba Betancourt2
1 University of Guanajuato, Guanajuato, Mexico.
2 Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Mexico.
*Corresponding Author: Cesar Elpidio Rodríguez Cervantes, University of Guanajuato, Guanajuato, Mexico.
DOI: https://doi.org/10.58624/SVOAMR.2023.01.001
Received: May 13, 2023 Published: July 31, 2023
Abstract
Obesity is associated with an increased inflammation involved in the development of atherosclerosis and insulin resistance. Macrophages are key in the genesis of these processes. Obesity induces macrophage accumulation in adipose tissue, they produce many of the inflammatory molecules secreted by adipose tissue like TNF-α, interleukins (IL-1β, IL-6, IL-8), as well as acute phase proteins such as haptoglobin (Hp), PAI-1 and C-reactive protein. The presence of these molecules in obesity relates this pathology to various inflammation degrees.The analysis of histological sections obtained from rabbit adipose tissue biopsy samples and processed by the hematoxylin-eosin and immunohistochemistry, showed the effect of metformin, a molecule which acts on the insulin metabolism, by the degeneration of this tissue during obesity. Metformin and its effects on metabolism are such that decreases the inflammation process suffered by adipose tissue, which is reflected by morphological changes in the distribution and migration of cells in the histological structure.
Keywords: Inflammation, histological section, monocyte, rabbit.
Citation: Cervantes CER, Betancourt CA. Effect of Metformin on Adipose Tissue Degeneration During Obesity. SVOA Medical Research 2023, 1:1, 01-06.