Tractography innovative knowledge of multiple sclerosis and trigeminal neuralgia
In Multiple Sclerosis (MS) pathophysiology, a detailed history is known to be the most innovative tool for clarifying the trigeminal nerve (TGN) and predicting its possible interaction. TGN is one of the largest and most engaged cranial nerves (CN) in MS pathology, which probably has received limited attention so far. In addition, it has a very active peripheral ascending and descending neural transport. Patients with classic trigeminal neuralgia (TN) will be used as a proxy to obtain additional information on MS pathology when symptoms are unilateral, with magnetic resonance imaging (MRI) showing bilateral pathology, and neurophysiological result supporting the MRI findings. Using MRI was found to raise the level of information on the microstructure and neural interconnection of TGN, for example, using the T2 and diffusion tensor imaging (DTI) with tractography can improve our understanding in this regard. Microvascular information with retrograde reflux of TGN venous contact can also be followed to the central venous branches in the corpus callosum and read out from the neurosurgical report. In this study, a sign of common demographical factors, such as predominantly female, younger ages, and side specific, white matter (WM) lesions when reviewing diffusion MRI data of naïve TN, and MS-TN was found. Other findings included anatomical differences, e.g., smaller diameter, volume, and greater atrophy, when looking through findings on female associated diffusion MRI. A tractographical comparison between TN patients without MS and TN patients with MS has facilitated a better understanding about the possible role of TGN in MS pathology.
Key words: Multiple Sclerosis , MRI, trigeminal neuralgia, TGN
Citation: Homayoun Roshanisefat. “Tractography innovative knowledge of multiple sclerosis and trigeminal neuralgia”. SVOA Neurology 1:1(2020) 24-38.
